Caixin Weekly | Salvaging Tuberculosis Patients (AI Translation)
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文|财新周刊 汤涵钰
By Tang Hanyu, Caixin Weekly
文|财新周刊 汤涵钰
By Caixin Weekly's Tang Hanyu
早晨8点,深圳市南山区一处交叉路口,交警暂时封闭狭窄的机动车道,让小学生们安心进入校园。隔壁三两家烧烤摊还没到热闹的时候,但公园里彩扇摇动,已有人在晨练跳舞。毗邻这个生活气息十足的街角,南山区慢性病防治院(下称“南山区慢病院”)15层的门诊楼拔地而起,紧挨一座四层小楼。也许少有人知道,这是当地结核病防治重镇:每年,这里要确诊全区近200平方公里内、181万常住人口中的约500名新发结核病患者——平均每天近1.5人。
At 8 a.m., at an intersection in Nanshan District, Shenzhen, traffic police temporarily closed a narrow lane, allowing elementary school children to enter their campus safely. Nearby, a few barbecue stalls hadn't yet reached their peak activity, but colorful fans were already waving in the park where people were practicing morning exercises. Adjacent to this bustling street corner, a 15-story outpatient building of the Nanshan District Chronic Disease Prevention and Treatment Center (hereinafter referred to as "Nanshan Chronic Disease Center") stands tall beside a four-story building. Perhaps few people realize that this is a key site for tuberculosis prevention in the area. Annually, about 500 new tuberculosis cases are confirmed among the 1.81 million residents within nearly 200 square kilometers of the district, averaging nearly 1.5 cases per day.
南山区是中国最“富有”的市辖区之一,2023年地区生产总值8566亿元,以不到深圳十分之一的土地创造了全市近四分之一的GDP,坐拥阿里、腾讯、华为、大疆等知名大厂。但即便在这里,古老的“白色瘟疫”亦未走远。
Nanshan District ranks among the wealthiest urban districts in China, boasting a 2023 GDP of 856.6 billion yuan. With less than one-tenth of Shenzhen's land area, it generates nearly a quarter of the city's GDP, hosting renowned giants such as Alibaba, Tencent, Huawei, and DJI. Yet even here, the ancient “white plague” is not a thing of the past.

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- Shenzhen's Nanshan District launched a pilot program for tuberculosis screening, revealing a higher incidence rate among seniors and diabetes patients. In China, around 700,000 TB cases go undetected annually.
- Challenges include patients' delay in seeking treatment and undetected infectious 'silent' carriers' contribution to TB spread. National plans emphasize proactive screening and new technologies.
- Effective TB control faces hurdles in resource allocation, screening implementation, and funding. Regional strategies tailored to local conditions aim to improve detection and reduce incidence rates.
[para. 1] In Shenzhen's Nanshan District, at the intersection of a busy district, an important site for tuberculosis prevention exists at the Nanshan District Chronic Disease Prevention and Treatment Center. Annually, about 500 new tuberculosis (TB) cases are confirmed among the area's 1.81 million residents, indicating that tuberculosis still poses a significant challenge even in wealthier parts of China.
[para. 2] Despite its economic prosperity, Nanshan District, like other areas in China, faces challenges in combating TB. Wealthy districts host major companies yet still confront this ancient disease.
[para. 3] In May, a local chronic disease hospital initiated a proactive TB screening program targeting senior citizens over 65 and diabetes patients. The screenings included questionnaires, chest X-rays, and blood and sputum tests. Results revealed higher TB infection rates in these groups.
[para. 4][para. 5] A nearby hospital treated a severely ill patient found by police after nearly drowning; he was diagnosed with advanced tuberculosis. Many similar cases exist among migrant workers who aren't often screened or covered by health checks, leading to potential hidden TB carriers due to their high mobility and lack of healthcare coverage.
[para. 6] TB patients remain hidden in developed cities, undetected and untreated. WHO estimates over 700,000 TB cases in China annually, but only about 500,000 are officially recorded, suggesting significant underreporting, with 20% of new cases slipping through the healthcare system unnoticed.
[para. 7][para. 8] Many patients don't seek medical help in time, contributing to TB's spread. Research indicates that 50%-70% of TB transmission occurs before patients seek medical attention. TB primarily affects the lungs and can spread through droplets when an infected person coughs or breathes.
[para. 9][para. 11] The "Expert Consensus on the Estimation of National Latent Tuberculosis Infection Rates" suggests 18.08% of people aged five and older are latently infected with TB in China, possibly developing into active TB. Despite China's efforts, patients are often detected through passive methods, with many not recognizing symptoms like fatigue or weight loss as indicators of lung disease.
[para. 11][para. 12] The Chinese government has recognized that proactive measures and new technologies are needed. In November, a plan was issued to enhance TB prevention and control. It acknowledged the disease's incidence rate has dropped but remains a serious threat. Efforts are uneven across regions, with a need to strengthen proactive patient screening.
[para. 13][para. 14] Various regions in China have been exploring proactive TB screening by combining symptom-based methods with chest imaging, particularly for high-risk groups like the elderly and diabetics. Regional differences must be accounted for in detecting and managing TB cases while leveraging new technologies for better diagnostics.
[para. 15] Screening, a key strategy to discover TB patients, requires significant investment. In Yunnan and Guangdong, TB incidence has seen significant declines due to enhanced proactive detection strategies. Implementations like mobile X-ray vans have been instrumental in some areas, aiding in early screening.
[para. 16][para. 17] New technologies like molecular diagnostics have improved rapid diagnosis rates; however, high equipment and reagent costs still hinder widespread implementation. Despite the availability of advancements like convenient tongue swabs, limited resources mean practical and cost-effective technology application remains constrained.
[para. 18] Globally, TB prevention efforts struggle with financial constraints, highlighting China's progress and emphasizing the need for tailored regional strategies considering economic capabilities.
[para. 19][para. 20][para. 21] China's system is well-positioned to eliminate TB, but challenges persist. Financial support, accurate screening, further public participation, and modernized strategies remain integral to the fight against TB. China aims for realistic, achievable goals to curb the epidemic by 2030, differing from more ambitious global targets set by WHO.
- Alibaba
- The article mentions that Alibaba is one of the well-known major companies located in Shenzhen's Nanshan District, one of China's wealthiest districts with significant economic output.
- Tencent
- The article mentions that Tencent is one of the well-known large companies located in Nanshan District, Shenzhen, which is described as one of the most "affluent" districts in China. In 2023, Nanshan District's GDP reached 856.6 billion yuan, generating nearly a quarter of Shenzhen's GDP with less than one-tenth of the city's land area.
- Huawei
- The article mentions that Huawei is one of the well-known major companies located in Shenzhen's Nanshan District, one of China's wealthiest municipal districts. Nanshan District is noted for contributing nearly a quarter of Shenzhen's GDP despite occupying less than a tenth of the city's total land area.
- DJI
- In the article, DJI is mentioned as one of the well-known major companies located in Shenzhen's Nanshan District, alongside others like Alibaba, Tencent, and Huawei. The district is noted for its significant economic contribution, creating nearly a quarter of Shenzhen's GDP on less than a tenth of the city's land. This highlights the district's economic importance and the presence of prominent tech companies, including DJI.
- Cepheid
- According to the article, Cepheid is mentioned as the maker of GeneXpert, a leading product in molecular biology testing for tuberculosis (TB). It is noted that the reagents for this equipment are expensive, with the Yunnan province procurement price at 350 yuan per unit. This cost presents a challenge for widespread application, as economic constraints limit the availability of these tests to confirm TB diagnosis.
- Perseverance Bio
- Perseverance Bio is one of the five companies preparing to submit an application for the approval of tongue swab products in China. They obtained an import medical device license from the Indonesian government in August, indicating progress in developing their tongue swab technology for tuberculosis screening.
- March 2024:
- Zhang Wenhong publishes a commentary about 'subclinical tuberculosis' and its role in global tuberculosis transmission.
- April 2024:
- 61-year-old Zhao Hua seeks treatment for tuberculosis in Kunming after experiencing symptoms for nearly two months.
- May 2024:
- Nanshan Chronic Disease Hospital launches a pilot program offering free tuberculosis screenings in five communities.
- Late Summer 2024:
- 70-year-old Wang Yan from Xinping County, Yuxi City, Yunnan, becomes a tuberculosis patient, approximately 20 years after his son was cured.
- October 2024:
- Wang Yan has been under treatment for over a month with pathogen tests turning negative.
- After October 2024:
- Caixin observes proactive detection strategies in Guangdong and Yunnan to combat tuberculosis.
- November 2024:
- WHO defines 'asymptomatic tuberculosis' at the 55th Union World Conference on Lung Health.
- November 28, 2024:
- The State Council approves the 'National Tuberculosis Prevention and Control Plan (2024–2030)' focusing on proactive patient detection and standardized treatment management.
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