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Indonesia Offers Case Study on Biopharma Industry’s Overseas Expansion (AI Translation)

Published: Jan. 11, 2025  2:32 p.m.  GMT+8
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2024年11月,位于雅加达东部的Etana工厂。Etana是承接中国合作最多的印尼医药企业,涵盖康希诺、科兴、沃森、艾博、信达等超过10家公司。图:周信达
2024年11月,位于雅加达东部的Etana工厂。Etana是承接中国合作最多的印尼医药企业,涵盖康希诺、科兴、沃森、艾博、信达等超过10家公司。图:周信达

文|财新周刊 周信达 发自印尼雅加达,赵今朝 发自北京

By Caixin Weekly's Zhou Xinda from Jakarta, Indonesia, and Zhao Jinzhao from Beijing

  每年11月,印度尼西亚步入雨季,空气闷热潮湿,穿行在最大城市雅加达南部市区的街头,鳞次栉比的高楼大厦上嵌着汇丰银行、安联保险、普华永道等跨国巨头公司的Logo,各国大使馆多驻扎在此。而一个十字路口之隔,马路对面却是拥挤、破陋的棚户区,小商贩沿街支起摊位,摩托车驶过灰尘四散,展示着这个东南亚国家的发展差异。

Every November, Indonesia enters its rainy season, characterized by hot and humid air. Walking through the southern district of the largest city, Jakarta, one sees skyscrapers adorned with logos of multinational giants such as HSBC, Allianz, and PwC. Various embassies also find their homes here. Yet, just across an intersection lies a stark contrast—cramped, dilapidated shantytowns. Street vendors set up stalls along the sidewalks, and the passing motorcycles kick up dust, illustrating the development disparities in this Southeast Asian nation.

  距这里20公里之外,是当地一家生物创新企业PT Etana Biotechnologies Indonesia(下称“Etana”)的产业园区。2025年新年第一周,一辆汽车载着沃森生物与其合作的印尼首支本地化生产13价肺炎球菌多糖结合疫苗(PCV-13)从这里驶出,运往政府位于雅加达的中央仓库。

Twenty kilometers from here lies the industrial park of the local biotech innovation company PT Etana Biotechnologies Indonesia (hereafter referred to as "Etana"). In the first week of 2025, a car carrying the first locally produced 13-valent pneumococcal conjugate vaccine (PCV-13), developed in collaboration with Watson Biologics, will depart from here for delivery to the government’s central warehouse in Jakarta.

  东南亚正成为中国医药企业新的掘金地。据普华永道《2015—2023年中国企业东南亚地区医疗行业投资回顾与展望》,八年间中企对东南亚医疗市场直接投资交易总额累计超66.19亿美元,交易数量从2015—2017年的年均3笔增加至2021—2023年的年均9笔,交易金额从2015年的5.33亿美元增加至2022年的15.96亿美元。

Southeast Asia is increasingly becoming a lucrative market for Chinese pharmaceutical companies. According to PwC's "Review and Outlook of Chinese Enterprises' Investment in Southeast Asia's Healthcare Industry, 2015-2023," the total amount of direct investment transactions by Chinese enterprises in the Southeast Asian healthcare market has exceeded $6.619 billion over eight years. The number of transactions has grown from an annual average of three between 2015 and 2017 to an annual average of nine from 2021 to 2023. The transaction value increased from $533 million in 2015 to $1.596 billion in 2022.

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Caixin is acclaimed for its high-quality, investigative journalism. This section offers you a glimpse into Caixin’s flagship Chinese-language magazine, Caixin Weekly, via AI translation. The English translation may contain inaccuracies.
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Indonesia Offers Case Study on Biopharma Industry’s Overseas Expansion (AI Translation)
Explore the story in 30 seconds
  • Indonesia's economy faces stark contrasts with high-rise developments and impoverished shantytowns, marked by a developing healthcare sector. The country, with a population of 280 million, is crucial in China's Belt and Road Initiative, serving as a strategic gateway.
  • Chinese companies are increasingly investing in Indonesia, with $6.619 billion transactions in Southeast Asia's healthcare market since 2015. Indonesia's appeal to Chinese investors has sharply risen, seeking opportunities to boost exports amid China's stagnant market.
  • Indonesian healthcare market challenges include stringent local regulations, lower purchasing power, and basic insurance coverage. However, growth potential exists, driven by population size, geopolitics, and industrial dynamics post-COVID-19.
AI generated, for reference only
Explore the story in 3 minutes

Indonesia's rainy season arrives each November, bringing hot and humid air. In Jakarta, the disparity between the opulently adorned skyscrapers of multinational corporations and the cramped shantytowns illustrates the broad development disparities in the country [para. 1]. Twenty kilometers away, PT Etana Biotechnologies is gearing up to launch Indonesia's first locally produced pneumococcal conjugate vaccine in collaboration with Watson Biologics. This move is part of a broader trend of Chinese pharmaceutical firms venturing into Southeast Asia [para. 1][para. 2].

Over the past eight years, Chinese firms have invested more than $6.619 billion in the Southeast Asian healthcare market. Indonesia, with its strategic location and a population of 280 million, forms a crucial link in this expansion [para. 3]. The country's importance as an investment destination has grown significantly, ranking second only to Singapore in the China Outbound Investment Index [para. 3][para. 4]. The bilateral ties between China and Indonesia, particularly in healthcare, have seen tremendous growth, highlighted by recent high-profile visits and agreements focusing on health cooperation [para. 5][para. 6].

China's pharmaceutical market is grappling with stringent policies that control health insurance costs, prompting companies to explore opportunities abroad. However, challenges persist in Indonesia due to its low per capita GDP, weak pharmaceutical foundations, and local protectionism [para. 7][para. 8]. The local market dynamics resemble China twenty years ago, as Indonesia targets ambitious growth goals under the Golden Indonesia 2045 vision, aiming to become a developed nation with an 8% economic growth rate [para. 9][para. 10].

Investors like Qiming Venture Partners understand that immediate profits in Indonesia are unrealistic, yet they emphasize the market's long-term potential [para. 10]. This is paralleled by the government’s push for localization of foreign companies, making local production a prerequisite for tapping into the public hospital system [para. 11][para. 12]. This process often requires a blend of local partnerships and thorough market understanding, as demonstrated by companies like Sansure Biotech, which opted for a direct subsidiary setup in Indonesia [para. 11][para. 12][para. 13].

Despite these hurdles, China’s biopharmaceutical sector sees immense potential in Indonesia due to less competition and favorable cost structures [para. 14][para. 15]. The strategic inclusion of Halal Certification also opens pathways to the broader Muslim market [para. 16]. Clinical trials often commence in Indonesia due to more lenient criteria and the capacity to leverage multi-center global trials [para. 17][para. 18]. However, this involves navigating local nuances, such as the distinct process of halal certification and overcoming gaps in Indonesia's healthcare research infrastructure [para. 19][para. 20].

Chinese enterprises are leveraging their advantages, such as lower production costs and expansive support networks, to establish a presence in Indonesia. The government's vision for health investments, coupled with the long-term stability of Sino-Indonesian relations, spells vast opportunities for growth [para. 21][para. 22]. Companies must navigate cultural and operational differences, invest in establishing mutual trust, and adapt business strategies to align with Indonesia's specific market and regulatory environment [para. 23][para. 24].

Collaborative efforts with other Chinese firms can enhance market education and acceptance of Chinese pharmaceutical products, driving the collective success of China’s "go global" strategy in the region [para. 25][para. 26]. Overall, for Chinese pharmaceutical companies, Indonesia presents a frontier filled with challenges but equally abundant in opportunity, promising a significant return on investment for those who adapt and endure [para. 27].

AI generated, for reference only
Who’s Who
HSBC Bank
汇丰银行
HSBC Bank's logo is mentioned as being displayed on the high-rise buildings in Jakarta, Indonesia, highlighting the presence of multinational companies in the city. The context contrasts Jakarta's developed areas, featuring global corporations, with the adjacent underdeveloped neighborhoods, illustrating the socio-economic disparity in the region.
Allianz Insurance
安联保险
The article mentions that Allianz Insurance is one of the multinational companies with its logo on high-rise buildings in the southern district of Jakarta, Indonesia's largest city. This indicates a presence of Allianz Insurance in the region, highlighting Jakarta's role as a hub for international businesses and its economic significance.
PricewaterhouseCoopers
普华永道
PricewaterhouseCoopers, also known as PwC, is mentioned in the article as one of the multinational companies with logos on skyscrapers in Jakarta, Indonesia. The article highlights Indonesia's development contrasts, where global giants like PwC have a presence alongside local economic challenges. PwC also conducted a review and outlook report on Chinese companies' investments in Southeast Asia's healthcare sector from 2015 to 2023, highlighting significant growth in investment and market interest.
Watson Biology
沃森生物
Watson Biology collaborated with PT Etana Biotechnologies Indonesia to produce Indonesia's first locally manufactured 13-valent pneumococcal conjugate vaccine (PCV-13). This vaccine was transported from Etana's industrial park to the government central warehouse in Jakarta in early 2025. Moreover, during the pandemic, Watson collaborated with Aibo to conduct international multicenter clinical trials for a new mRNA COVID-19 vaccine in Indonesia, Mexico, and the Philippines.
Innovent Biologics
信达生物
Innovent Biologics collaborates with Indonesia's Etana, granting exclusive local production rights for its Bevacizumab injection in Indonesia. By 2024, Bevacizumab has been locally produced and approved by Indonesia's BPOM, capturing a significant market share amid insufficient coverage of innovative and biosimilar drugs in Indonesia's healthcare system, thereby highlighting market potential for further inclusion in healthcare plans.
Sansure Biotech
圣湘生物
Sansure Biotech established a subsidiary in Indonesia in 2021. They initially planned to focus on hepatitis prevention but shifted to developing localized tuberculosis detection products in response to local needs. They also signed a collaboration memorandum with Indonesia's UBC Medical to begin localized production, launching operations in a Jakarta-area plant to produce infectious disease and public health diagnosis products, and adapting management to local conditions.
Wondfo Biotech
万孚生物
Wondfo Biotech has structured its Indonesian market strategy into three phases: "Going Abroad 1.0" focused on initial trade, "Going Abroad 2.0" emphasized local adaptation with product sales, and "Going Abroad 3.0," aims to influence the immunodiagnostics market there. They anticipate more robust market development and rely on various stakeholders, including partnerships with research institutions, to improve diagnostic processes.
CanSino Biologics
康希诺
CanSino Biologics accelerated its overseas market growth during the COVID-19 pandemic, utilizing its adenovirus vector vaccine's less stringent storage requirements and single-dose effectiveness. Initially engaged in overseas clinical research during the 2014 Ebola outbreak, CanSino found opportunities in Indonesia amid the pandemic. Post-pandemic, Indonesia sought to escape mere product importation, focusing more on vaccine technology research and talent development, benefiting companies like CanSino.
BGI Group
华大集团
In 2022, BGI Group signed three cooperation memorandums with the Indonesian Ministry of Health, Universitas Indonesia, and Del Institute of Technology. The agreements focused on genomic development initiatives, joint research, talent training, and the establishment of related laboratories. BGI also participated in Indonesia's first "National Genome Project" as a designated sequencing platform. A year later, BGI collaborated with PT Kalbe Farma Tbk to conduct thalassemia prevention research and screening.
Sinovac
科兴
Sinovac's subsidiary manager, Wang Zenghui, mentioned that Sinovac's approach in Indonesia involves preparing the raw vaccine liquid domestically and then shipping it to Indonesia for local partner Bio Farma to finalize the product through local packaging. This strategic collaboration covers registration, marketing, and sales, ensuring that Sinovac's products are well-integrated into the Indonesian market, positioning them favorably for inclusion in national immunization programs.
Zhifei Biological
智飞生物
Zhifei Biological's subsidiary, Anhui Zhifei Longcom, received approval for its recombinant tuberculosis protein fusion vaccine in Indonesia in October 2024. This development is part of their efforts to introduce more vaccines to the Indonesian market.
BeiGene
百济
The article mentions BeiGene as a leading Chinese innovation drug company, which typically targets the high-return U.S. market for new drug exports. In contrast, products with lower innovation content or those launched years ago are often considered for the Indonesian market, even though the quality of Chinese products remains ahead of local pharmaceutical companies.
Junshi Biosciences
君实
The article does not specifically mention Junshi Biosciences. However, it discusses China's broader pharmaceutical sector's interest in the Southeast Asian market, particularly Indonesia, as companies seek new opportunities due to domestic constraints. China’s pharmaceutical industries, possibly including companies like Junshi Biosciences, are exploring international collaboration, local production, and regulatory pathways to establish a presence in countries like Indonesia.
BYD
比亚迪
In the article, BYD is mentioned as one of the Chinese brands commonly seen on the streets of Jakarta, Indonesia. It highlights that BYD, along with other Chinese brands like Wuling, has become popular among locals, which supports the perception of Chinese products as reliable and quality options.
Wuling
五菱
The article mentions Wuling as a brand seen commonly on the streets of Jakarta, Indonesia. Wuling, along with BYD, is cited as an example of successful Chinese automotive brands that have gained popularity and recognition for quality in Indonesia. This indicates the potential for other Chinese products to be well-received in the region.
Vivo
维沃
The article mentions that in Jakarta, many local people use Vivo phones. This is highlighted as part of the broader trend of Chinese products gaining recognition for quality, similar to how Chinese cars like BYD and Wuling are common on Jakarta streets. This reflects the successful "outbound" push of Chinese consumer electronics, improving perceptions of Chinese products in foreign markets.
OPPO
欧珀
In the article, it is mentioned that OPPO is commonly used by locals in Indonesia, alongside other Chinese brands like BYD and Vivo. This highlights the presence and acceptance of Chinese products in the Indonesian market, suggesting that they are associated with quality and reliability.
AI generated, for reference only
What Happened When
2019:
Sansure Biotech met Indonesian distributors at an exhibition in Jakarta.
2020:
Indonesia's national healthcare expenditure accounted for 3.4% of GDP.
December 2020:
1.2 million doses and 1.8 million doses of Sinovac's COVID-19 vaccine, CoronaVac, were sent to Jakarta.
September 2021:
CanSino's COVID-19 vaccine, Convidecia, was granted emergency use authorization.
January 2024:
Henlius' serplulimab was shipped to Indonesia.
April 2024:
Indonesian President Prabowo chose China for his first overseas visit after winning the election and being officially inaugurated.
June 2024:
CanSino Biologics began work to apply for clinical approvals for its tuberculosis booster vaccine in Indonesia.
July 2024:
Innovent Biologics' Bevagen completed localized mass production and received approval for market launch in Indonesia.
October 2024:
A recombinant Mycobacterium tuberculosis fusion protein by Anhui Zhifei Longcom was approved for market release in Indonesia.
November 2024:
Sansure Biotech attended the 55th Union World Conference on Lung Health in Bali.
November 2024:
A joint statement was released by China and Indonesia emphasizing the implementation of health cooperation agreements.
December 2024:
CanSino's meningococcal polysaccharide conjugate vaccine ACYW135 was granted a registration certificate in Indonesia.
By end of 2024:
An interprovincial collective procurement alliance for in vitro diagnostic reagents was expected to be led by Anhui region.
2024:
Interactions in public health and medicine between China and Indonesia have intensified.
January 6, 2025:
Indonesia is set to become an official member of the BRICS countries.
First week of 2025:
A car carrying the first locally produced PCV-13 vaccine will depart for delivery to the government's central warehouse in Jakarta.
AI generated, for reference only
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