She is the editor of the book Cultivating Confidence: Monitoring, Verification, and Enforcement for a World Without Nuclear Weapons (Hoover Institution Press, 2010) and author of short-form writing that has appeared in leading international journals and newspapers. Hinderstein is a past president and fellow of the Institute of Nuclear Materials Management and served on the board of directors for the World Institute for Nuclear Security. She has also served in advisory capacities for multiple U.S. national laboratories.
Prior to joining Carnegie, she was the acting principal deputy administrator for the National Nuclear Security Administration and the deputy administrator for Defense Nuclear Nonproliferation. Before her confirmation by the Senate in 2021, Hinderstein was a vice president at the Nuclear Threat Initiative.
她是《培育信心：无核武器世界的监测、核查与执行机制》（Cultivating Confidence: Monitoring, Verification, and Enforcement for a World Without Nuclear Weapons，胡佛研究所出版社，2010 年）的编辑，并曾在多家国际知名期刊和报纸上发表短篇文章。Hinderstein 曾担任国际核材料管理学会主席及会士，并曾在世界核安全研究所董事会任职。她还曾以顾问身份为多个美国国家实验室提供服务。
加入卡内基之前，她曾担任美国国家核安全管理局代理副局长，以及负责防务核不扩散事务的副局长。在 2021 年获得美国参议院确认任命之前，Hinderstein 曾担任核威胁倡议组织副总裁。